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Results were considered statistically significant at p 80%) and concerns regarding imprecision and risk of bias were the main factors contributing to downgrading (Supplementary Table S3)

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It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesn’t necessarily mean that if you tolerate methylfolate well you’ll also need, want or tolerate methylcobalamin well (even if that’s what most doctors, nutritionists, etc