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A systematic review published in orthopaedic sports medicine literature identified 36 studies from 1993 to 2024

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Vertebrates have developed a somatotropic axis, which involves the production of pituitary growth hormone (GH), whose secretion is controlled by hypothalamic stimulatory and inhibitory neuropeptides, including growth hormone-releasing hormone (GHRH) and somatostatin (4, 5)