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7 A recent randomized, double-blind, placebo-controlled clinical trial to assess the efficacy of 3% propolis ointment (Herstat) in patients with a history of HSV-1 infection showed a mean healing time of 6.24 days, compared to 9.77 days in the placebo group, along with better pain relief

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Gastrointestinal Histology As in previous studies [12,13,14,15,16,20,22,23,24], we used a histologic scoring scale adapted from Chui and coworkers [52] for the intestinal tissue damage, scoring 0–5 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 0 to 15, as described by Lane and coworkers [53]