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Despite their well-documented anticancer activities (Table 3), ITCs have been found to exhibit hormetic activities in tumor cells, which involve GSH amount in a biphasic dose-response relationship, wherein low doses of these compounds can induce beneficial effects while high doses may be detrimental in different cancer models in vitro and in vivo [133,134,135]

scientific investigation

Size:200 µg

Regarding oxidative stress, the enzymatic systems that contribute the most to the generation of ROS include the proteins that are bound to the plasma membrane, such as the family of NADPH oxidases [17,18], the enzymatic systems that participate in the lipid metabolism within peroxisomes and the activity of various cytosolic enzymes such as cyclooxygenases