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116,129,130 Two classes of enzymatic components, glutathione reductases (GRs) and thioredoxin reductases (TrxRs), are homologous flavoenzymes that use electrons from NADPH to reduce a disulfide to a dithiol

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This phenomenon can be caused by the fact that the released elemental mercury can be re-oxidized in the intracellular compartment by several enzymes, such as catalase [120,121] and re-enter the catalytic GSH-depleting cycle, ultimately leading to a displacement of the intracellular redox potential towards less negative, pro-apoptotic or necrotic values

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