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Wave shelves · perforated field sheets
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Ethanol-induced oxidative damage in the liver involves depletion of antioxidants (especially GSH in the mitochondria), lipid peroxidation, and protein modifications (carbonylation, addition of 4-HNE, and nitration of tyrosine residues)
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Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)
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