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However, as a heavy metal, chronic exposure and bioaccumulation of chromium can lead to significant toxicity and diverse pathophysiological impairments, including allergic reactions, anemia, dermal burns, and ulcerative lesions—particularly in the stomach and small intestine—as well as spermatogenic damage and male reproductive system dysfunction, ultimately affecting multiple biological systems (101)

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Valproic acid overcomes hypoxia-induced resistance to apoptosis