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It has been reported that EPA can inhibit the phosphorylation of p38 and downregulate the expression of MAPK, p53, MMP3, MMP-13, and caspase 3, resulting in reduced chondrocyte apoptosis, thereby improving OA (Sakata et al ., 2015)
GSH
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This can lead to the silencing of a proportion of the normal synaptic contacts and result in decreased excitation of the postsynaptic neurons
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