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Glutathione peroxidase catalyzes reactions in which the enzyme reduces hydrogen peroxide to water, as well as organic hydroperoxides (ROOH) to hydroxy derivatives, resulting in the conversion to the oxidized disulfide form GS-SG: H2O2 + 2GSH = GS-SG + H2O ROOH + 2GSH = GS-SG + ROH +H2O Glutathione peroxidase neutralizes peroxynitrite: ONOO- + 2GSH → NО2- + GSSG + 2Н2О Glutathione reductase is a flavoprotein with a flavin adenine dinucleotide prosthetic group and consists of two identical subunits
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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
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