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Although high selectivity of PAG for CSE over CBS has been reported (i.e., an IC 50 of 40 μM for the CSE-catalyzed reaction using 1 mM of cysteine as the substrate, with no detectable inhibition of CBS even at 10 mM PAG), it also inhibits several other PLP enzymes, such as aspartate aminotransferase, alanine aminotransferase, and methionine γ -lyase (Sun et al., 2009)