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Additionally, under pathological conditions, SIRT1 activation by adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), a key energy sensor that regulates cellular metabolism and stress responses, further attenuates inflammatory signaling

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They act together along with cells of the adaptive immune system, T and B lymphocytes, and reach the inflammation site within minutes to support a quick and precise response to subsequent infection [142]