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DOI: 10.1128/CMR.00023-08 12
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In addition, O 2 · − reacts with nitric oxide (NO) to generate peroxynitrite (ONOOˉ) (Figure 2), which targets DNA, proteins, and lipids, causing DNA damage, dysfunction of enzymes, receptors, transporters, and membrane channels, as well as protein aggregation, mitochondrial dysfunction, and lipid peroxidation [15]
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