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Recently, we reported the discovery of one series of GPX4 allosteric activator compounds (Li et al., 2018) by using a combining approach of potential binding cavity identification (Yuan et al., 2011, 2013), allosteric site prediction (Ma et al., 2016), and allosteric ligand virtual screen

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Drug solution preparation Except for dihexa all drug solutions were prepared in HPLC grade water at 5 mg/ml