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Similar to their findings with the human GCLC promoter, Mulcahy and colleagues demonstrated that up-regulation of the human GCLM by β-NF involved binding of Nrf2 (possibly in complexes with other Jun or Maf proteins as in GCLC) to a functional ARE/EpRE site located at −302 of the human GCLM (Moinova and Mulcahy, 1999
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