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While γGTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of γ-glutamylcyclotransferases (γGCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)
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doi: 10.1096/fasebj.27.1_supplement.1093.26
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