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Conclusion This RCT provides evidence to show that GlyNAC supplementation in OA improves GSH deficiency, OxS, mitochondrial impairment, mitophagy, inflammation, insulin resistance, endothelial dysfunction, physical function and strength, exercise capacity, waist circumference, state systolic blood pressure, and multiple hallmarks of aging (mitochondrial dysfunction, altered intercellular communication, dysregulated nutrient sensing, loss of proteostasis, genomic toxicity, stem-cell exhaustion, and cellular senescence)

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Reviews Reduced glutathione (L-γ-glutamyl-L-cysteinylglycine), a tripeptide, serves as a key antioxidant in animal, plant, fungi and bacteria by providing free thiol