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Near the cytoplasmic end of the membrane the helices are held together by an inner membrane clasp composed of the integrin α IIb residues immediately after the end of the helix (GFFKR), with the membrane reimmersion of F992 and F993 filling the gap and interacting with integrin β 3 W715 and I719, with integrin α IIb R995 creating a salt bridge with integrin β 3 723 and perhaps residue 726

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General considerations include: The FDA notes that sterile products should be handled using appropriate aseptic procedures and stored according to manufacturer guidance throughout their period of use