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There are four groups of PTPs (based on their substrate recognition): (i) non-receptor PTPs such as SHP1 and SHP2, (ii) receptor tyrosine phosphatases such as CD45, (iii) dual-specificity phosphatases, and (iv) low molecular weight phosphatases (136)

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The study suggests that COS administration treats SAP by reducing oxidative stress and restoring intestinal homeostasis (Mei et al., 2021)